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Additionally, it causes both microgliosis and astrogliosis, which is characterized by increased astrocytic proliferation in rat cortex and striatum accompanied by a marked expression of GFAP [92,93]

Herein, we discuss some critical examples of representative synthetic compounds

Copper binding is what activates most of the documented biological effects strong Cu(II) chelators such as bathocuproine, which strip the copper from GHK-Cu, abolish its actions on collagen synthesis, wound healing, and gene expression in published in-vitro assays [3]

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